Nephrotic syndrome are prone to cause thrombosis

Nephrotic syndrome is a massive proteinuria, hypoalbuminemia, edema, hyperlipidemia its clinical features of a group of syndrome, caused by a variety of reasons, which can also cause a variety of complications. There are four common complications:

1 infection

Due to a large number of immunoglobulin lost from the urine, plasma protein reduces the impact of antibody formation. Adrenocorticotropic hormone and application of cytotoxic drugs, so patients with systemic defenses are weakened, prone to infection, such as skin infections, primary peritonitis, respiratory tract infections, urinary tract infections, and even induced sepsis.

2, metabolic diseases

Repeated or prolonged use of diuretics unreasonably ban salt, can make patients with nephrotic syndrome secondary to hyponatremia; adrenocorticotropic hormone use and a lot of diuretics cause a lot of urination, if not timely potassium, prone to hypokalemia .

3, cardiovascular disease

Nephrotic syndrome patients prone to blood clots, especially in membranous nephropathy incidence of up to 25% to 40%. The reason thrombosis edema, less patient activity, venous stasis, high cholesterol, blood viscosity increases so concentrated, high levels of fibrinogen and v, Ⅶ, Ⅷ, x factor increases and the use of adrenocorticotropic hormone and blood-prone hypercoagulable state and so on.

In addition, patients often have hyperlipidemia and hypercoagulable states nephrotic syndrome, and therefore prone to coronary heart disease. It was reported that patients with nephrotic syndrome, the incidence of myocardial infarction eight times higher than normal. Coronary heart disease has become the third leading cause of death nephrotic syndrome factors (after infection and renal failure).

4, the impact on renal function

Patients with nephrotic syndrome due to massive proteinuria, hypoalbuminemia, hyperlipidemia, body and often in hypovolemic hypercoagulable state. Vomiting, diarrhea, the use of antihypertensive drugs and diuretics lot diuretic, can make a sharp reduction in renal blood perfusion, thus reducing the glomerular filtration rate, leading to acute renal failure. In addition, nephrotic syndrome and renal interstitial edema, tube blockage formation of tubular protein concentrate and other factors can also induce acute renal failure.


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