Acute interstitial nephritis - Treatment

Acute interstitial nephritis, a sudden inflammation in renal interstitial edema, inflammatory cell infiltration, tubular degeneration showed different degrees of renal insufficiency with a syndrome of acute interstitial customarily referred to by a variety of causes nephritis. Because of the glomeruli and renal vascular disease most normal, and people used to call it glomerulonephritis different. The disease is a common cause of infection and drugs, another part of the patient to find the cause and not specifically called idiopathic acute interstitial nephritis. The disease is no obvious geographical distribution, in addition to drug-induced acute interstitial nephritis with the use of a drug related, infectious or idiopathic acute interstitial nephritis, all with women than men, especially common in young women, However, the incidence of older men is also high. 90% of patients the disease is treatable, and pathological damage is heavy or not treated, improper treatment, could be left behind and cause permanent renal dysfunction with impaired renal function.

(A) disabled after removing allergens sensitizing drugs, the majority of mild acute interstitial nephritis can gradually relieve itself.
(B) immunosuppressive therapy in severe cases should be taking corticosteroids such as prednisone daily 30--40mg, tapering condition improved, taking a total of 2-3 months, can accelerate disease remission. The indications for the use of hormones:
1, after stopping the drug delayed recovery of renal function;
2, diffuse interstitial cell infiltration or granuloma formation;
3, a sharp deterioration in renal function;
4, severe renal dialysis. For shock therapy or oral. Rarely need and use of cytotoxic drugs.
(C) cases of acute renal failure on dialysis dialysis treatment should be timely better prognosis of acute interstitial nephritis, mostly reversible, few patients can be left kidney damage, and the development of end-stage renal failure. The prognosis is mainly severity of the disease, renal function, the degree of renal interstitial infiltrates, acute renal failure, duration and age and so on.

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