Chronic glomerulonephritis (referred to as chronic nephritis), a variety of pathological types of primary glomerular disease is a common consequence of the course through the vast majority of primary glomerular disease will develop from persistent chronic nephritis , only minimal change nephrotic syndrome of primary disease, rarely develop to chronic nephritis.
The disease is characterized by a relatively long period before the disease asymptomatic urinary abnormalities, such as proteinuria and (or) hematuria, then slowly hypertension, edema and (or) azotemia, often quite a long time process, gradually kept nephron destruction, and finally lead to chronic renal failure.
Many people mistakenly believe that acute nephritis and chronic nephritis are two stages of the same disease, chronic nephritis is evolved from acute nephritis, like delayed healing of acute hepatitis to chronic hepatitis, like, in fact, this is a misunderstanding. We should first be clear that chronic nephritis and acute nephritis are two different diseases. Their pathology, clinical presentation, treatment and prognosis all have different characteristics. Some people think that chronic nephritis may have 15% to 20% of acute nephritis evolved. But the vast majority of chronic nephritis is not evolved from acute nephritis, chronic nephritis onset that is, which is determined by the patient's type of glomerular pathology decision. Pathological changes of acute nephritis glomerular capillary proliferation; pathological changes of chronic nephritis there mesangial proliferative glomerulonephritis, membranous nephropathy, mesangial proliferative glomerulonephritis, focal segmental glomerulosclerosis other.
Patients suffering from symptoms of chronic nephritis have great differences, someone with this kind of performance-based, someone Youyi Another performance-based. But early on, probably only showed increased urinary protein, mildly abnormal urinary sediment, mild hypertension and (or) edema, or even a slight azotemia. To the late, can be expressed as chronic renal failure, from early to late, it is possible to experience decades. Chronic nephritis is usually expressed as the number of cases of the following: ① general clinical manifestations of chronic nephritis: moderate persistent proteinuria and (or) abnormal urinary sediment. Mild edema and (or) mild hypertension, some patients may have mild azotemia; Some chronic nephritis can always no edema, but most patients with hypertension will happen sooner or later, can be mild or severe. ② a small number of patients in the clinical manifestations of the underlying common type on, but for the outstanding performance in hypertension, diastolic blood pressure (low pressure) is often moderate elevated, over time patients can occur Hypertensive heart and brain vascular disease, the type often misdiagnosed as essential hypertension. ③ acute exacerbation of chronic nephritis: acute, non-specific infection after a few days, proteinuria and abnormal urinary sediment aggravation, deterioration of renal function over a period of time in the future, often automatically reduced, restored to its original condition. Much like the performance of acute nephritis, should pay attention to identification.
The method is not particularly effective in the treatment of chronic glomerulonephritis, only symptomatic treatment. Hormones, cytotoxic drugs, nonsteroidal anti-inflammatory drugs, anticoagulant therapy, has not yet been clearly established whether the effect. For hypertensive vascular converting enzyme inhibitors were available. On the occurrence of respiratory tract infections, urinary tract infections and other infections should be given appropriate treatment, limiting the intake of protein and phosphorus when azotemia, can slow down the speed of progression of the disease. Try not to use drugs damage the kidneys, such as aminoglycoside antibiotics, amphotericin B and so on. Diuretics used only when there is an obvious hypertension and edema. Edema and hypertension control should be based on the situation, adjust salt intake; strict sodium restriction is not necessary, and may be dangerous. Congestive heart failure, or when there is no apparent hypoalbuminemia, chronic glomerulonephritis rarely severe edema disease will occur until late. Generally do not need to limit potassium intake.
For chronic nephritis can try traditional Chinese medicine. According to many scholars reports and our experience, Integrative better therapeutic effect.
Chronic nephritis prognosis is good or bad can not be generalized, it is with the clinical manifestations and pathological changes are closely related. Such as membrane proliferative glomerulonephritis poor prognosis, most chronic renal failure in a few years, and finally died of uremia. Focal segmental glomerulonephritis prognosis is poor, between the renal tubular atrophy and interstitial fibrosis or poor prognosis. High blood pressure over 170/110 mm Hg, the prognosis is poor. Elevated serum creatinine have been patient, the prognosis is poor.
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