Complications inventory nephrotic syndrome

(1) infection: Because of the loss of a large number of immune globulin from the urine, plasma protein reduced the impact of antibody formation. Adrenocorticotropic hormone and application of cytotoxic drugs, so that patients with systemic resistance decreased, prone to infection, such as skin infections, primary peritonitis, respiratory infections, urinary tract infections, and even induce sepsis.

(2) coronary heart disease: patients often have hyperlipidemia and hypercoagulability nephrotic syndrome, and therefore prone to coronary heart disease. It was reported that patients with nephrotic syndrome, the incidence of myocardial infarction eight times higher than normal. Coronary heart disease has become the third cause of death in the nephrotic syndrome factors (after infection and renal failure).

(3) thrombosis: nephrotic syndrome patients prone to blood clots, especially in membranous nephropathy incidence of up to 25% to 40%. Reasons for the formation of blood clots edema, less patient activity, venous stasis, high cholesterol, blood viscosity increases so concentrated, high levels of fibrinogen and v, Ⅶ, Ⅷ, x factor increases and the use of adrenal hormones and blood-prone hypercoagulable status.

(4) with acute renal failure: patients with nephrotic syndrome due to massive proteinuria, hypoalbuminemia, hyperlipidemia, body often in hypovolemic and hypercoagulable state? District vomit, diarrhea, when the use of antihypertensive drugs and diuretics large number of diuretic, can make a sharp reduction in renal blood perfusion, thus reducing the glomerular filtration rate, leading to acute renal failure. Furthermore, nephrotic syndrome and renal interstitial edema, tube blockage formation of tubular protein concentrate and other factors can also cause acute renal failure.

(5) electrolyte and metabolic disorders: Repeated or prolonged use of diuretics unreasonable ban salt, can make patients with nephrotic syndrome secondary to hyponatremia; use of adrenal corticosteroids and diuretics lead to a lot urinate a lot, if not promptly fill potassium, prone to hypokalemia.

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