Renal failure patients adjust the dose of medication in a timely manner

Patients with renal failure, substance renal excretion decreased metabolism in the body, so that these substances accumulate in the body, is also true for drugs, some drug or metabolite itself to be excluded by the kidneys, so as a result of renal failure, although medication the amount is conventional amounts, which should be a product of metabolism or drug still accumulate in the body, which can cause the drug poisoning, so in patients with renal failure, the correct adjusted dose is very important.
If you use primarily by renal excretion of the drug, if it is still the usual amount, you can in the blood and tissues of savings reach toxic levels, while poisoning symptoms. Such symptoms are often masked symptoms of uremia patients, and not easily detected, causing poisoning tragedy; if the drug nephrotoxicity, it will lead to rapid deterioration of renal function, it must not careless.
In the medication, depends on the specific circumstances of drug metabolism and excretion pathways, renal function (based on creatinine clearance rate mainly), and dialyzed against the ability to clear the drug, the dose is adjusted. Drug dosage renal failure when, according to the drug slowed clearance decreased, but also to maintain an effective concentration in the blood.

In general, the first dose of the drug can be used a normal amount, but later the dose necessary to reduce, how reduction, each drug is different, the doctor check renal failure drug use table, can know.
Dialysis (hemodialysis), peritoneal dialysis (PD) of the patients, etc., taking the amount of the drug should also be carried out under the guidance of a doctor.

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