Six methods for treating nephritis

Acute glomerulonephritis (acute glomerulonephritis) is often referred to as acute nephritis. Refers to a broad set of different etiology and pathogenesis, but the clinical manifestations of acute onset, hematuria, proteinuria, edema, hypertension, and is characterized by glomerular filtration rate decreased glomerular diseases, it is also often referred to as acute nephritic syndrome (acute nephritic syndrome).

First, the general treatment of bed rest, into the low salt, low-protein diet, the protein per kg body weight per day, and water quality according to the principles of treatment of acute nephritis. Correction of metabolic acidosis and prevention of hyperkalemia.

Second, the plasma exchange therapy aims to remove circulating antigens, antibodies, immune complex-mediated and inflammatory substances present multi plasma exchange means (large diameter fiber membrane by ultrafiltration), the separation of plasma and blood cells, the plasma is removed, each 2-4 liters a day or every other day, and then pay back the same amount of healthy fresh plasma or 4% human albumin Ringer. Applications often need the therapy with corticosteroids and cytotoxic immunosuppressive agents. Such as prednisone 60mg / day, cyclophosphamide 3mg/kg / day, plasma exchange therapy Ⅰ, type Ⅱ better patient outcomes, but the price expensive.

Third, corticosteroid pulse therapy with methylprednisolone 0.5 ~ 1.0g intravenously, daily or every other day 3 to 7 times; later changed to oral prednisone daily 40 ~ 80mg, 3 ~ 6 months after descending, the whole course of treatment for about a year. The method Ⅱ, Ⅲ type patient outcomes acceptable.

Four, quadruple therapy that corticosteroids, cyclophosphamide, heparin, dipyridamole combination therapy. Corticosteroid dosage and method as above; cyclophosphamide daily 150-200mg, intravenous, 1 day, 10 times as a course of treatment, total 6 ~ 12g; heparin 60-100mg, once daily, intravenous infusion or subcutaneously (dosage of medication prior to prolong clotting time than doubled for the degree); dipyridamole 200 ~ 300mg / day, 3 times service. Heparin and dipyridamole four weeks for a course of 7 to 10 days of intermittent repeatable effect. The total course of three months to six months, the most widely used method in clinical practice, its efficacy is hard affirmed.

Fifth, because oxygen radicals antioxidants applications involved in the inflammatory injury, there are applications SOD and large doses of vitamin E (dose: 1g / square meter of body surface area) in the treatment of this disease and get treatment.

Sixth, fibrinolytic therapy with urokinase 2 to 60,000 u / day, plus 5% glucose solution 20ml, intravenous, or added to 250ml of 5% glucose solution intravenously, 10 times as a course of treatment interval of 7 days, practicable a course of treatment, a total of three courses.