Clinical manifestations of IgA nephropathy

Clinical manifestations of IgA nephropathy varied , with a clear regional differences , its clinical manifestations are of two types.
( 1 ) patients with upper respiratory infections or gastrointestinal tract, 1 to 2 days after a urinary tract infection , gross hematuria , lasted for several hours or several days, became microscopic hematuria , after having varying degrees of proteinuria or microscopic hematuria. A few patients may have a transient high . Blood pressure and blood urea nitrogen levels , and even individual patients with acute oliguric renal failure syndrome , but after symptomatic treatment and rest can be mitigated. After the disappearance of gross hematuria , about 60 % of patients will relapse after a respiratory infection , hematuria again . Some people think that can reduce or eliminate hematuria after tonsillectomy . This type is more common in children , about 80% to 95 % of children with IgA nephropathy showed gross hematuria.
( 2 ) patients with asymptomatic urinary abnormalities , only to find microscopic hematuria and mild proteinuria , occasionally casts in the examination . Small number of patients with nephrotic syndrome, severe hypertension and chronic renal failure.
Laboratory tests: red blood cells in urine for more than 70 % of the examination phase deformation of red blood cells ( strawberry -like , spore -like, donut -like , etc. ) , urine red blood cell volume becomes smaller. A check of about 20% in patients with elevated serum IgA , continuous or repeated checking IgA increased about 40 % of patients . About 50 % to 90 % of patients with serum IgA- fibronectin polymer increased, and better specificity. Serum complement C3, CHso normal .