iag kidney, what is the underlying cause of proteinuria

What are the underlying causes of proteinuria is ? Jingdong experts, proteinuria is a big typical symptoms of kidney disease , but the number of leaking urine protein and does not reflect the severity of kidney disease . So, what are the underlying causes of proteinuria ? Here we ask the experts for everyone Jingdong detailed introduction about it !
Proteinuria protein leakage renal pathological damage does not necessarily mean less light ; massive proteinuria can not explain the severe kidney disease pathology damage. Such as minimal change glomerulonephritis and mild mesangial proliferative glomerulonephritis , mild kidney disease , but the daily amount of protein in the urine and even a few grams up to a dozen grams.
Proteinuria generally divided into selective proteinuria , non-selective proteinuria. Selective proteinuria , refers to a protein electrophoretic characteristics are mainly low molecular weight proteins , such as albumin , α -globulin , γ -globulin and transferrin . Large molecular weight proteins such as α less globulin, fibrinogen , β lipoprotein levels .
In minimal change nephropathy, mild mesangial proliferative glomerulonephritis , membranous proliferative glomerulonephritis and focal segmental sclerosis glomerulonephritis membranous nephropathy in patients with partial and early lesions showed more selective proteinuria , indicating a small network ( kidney small ball filtration membrane ) less damage . Non-selective proteinuria, characterized by means of protein electrophoresis protein macromolecules and small molecules simultaneously , indicating a small network ( glomerular filtration membrane ) damage is more serious .