Renal excretion is not only an important human organs, but also an important endocrine organ. Vitamin D is an important substance in the human body, but only when it is activated on human sense. And the activation is carried out in the kidney. Tubular cells mainly proximal tubule cells containing hydroxylase, which can catalyze vitamin D3 into active vitamin D3. Dietary intake of vitamin D3 and vitamin D3 7- cortex contained dehydrocholesterol by ultraviolet role in the formation of the first hydroxylation in the liver to 25-hydroxy cholecalciferol enzyme. The latter is via the kidney of 1a- hydroxylase synthesis 1,25- (OH) 2D3. The kidney 1a- hydroxylase synthetic 1,25- (OH) 2D3 of key enzymes. In renal 1,25- (OH) 2D3 also be hydroxylase as 24,25- (OH) 2D3.
1,25- (OH) 2D3's main role: ○ 1 to promote the tubular reabsorption of calcium. ○ 2 to promote intestinal absorption of calcium and phosphorus. ○ 3 promote cartilage calcification, bone tissue osteoclast activity to strengthen and increase the release of calcium in the blood circulation.
When kidney disease occurs, active vitamin D3 generation were reduced, reducing the absorption of calcium, calcium reduced resistance to increase vitamin D may be caused by reduction of bone mineralization, leading to renal osteodystrophy. In the past due to the dialysis technology is not mature enough, the majority of patients with a shorter survival time, and therefore found that patients with renal osteodystrophy is not much. As in recent years, dialysis techniques become more sophisticated, the incidence of renal osteodystrophy is gradually rising, promote kidney function activated vitamin D has also been doctors and patients more and more attention.
Currently, the clinical use of a-D3, calcium Lo full and so is this for kidney function developed and achieved good clinical efficacy.
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