To emphasis cause of diabetic nephropathy

Everyday life, people with diabetes are no longer a minority, in the past this disease is more common in the elderly, but in recent years, many young people suffering from the disease. Did you know? After suffering from diabetes, with the development of the disease, but also cause serious damage to the kidneys, which is a common clinical diabetic nephropathy, let's take a look, leading to what is the cause of the disease.
Of causes of diabetic nephropathy:
1, the genetic factors. This factor is the most major factors are responsible for diabetic nephropathy, many of the patients are suffering from this disease because of this factor in our lives there are a lot of good glycemic control may also occur in patients with diabetic nephropathy. Glucose transporter protein is the major glucose transporter in mesangial cells. And the occurrence of diabetic nephropathy also showed family aggregation.
2, high blood pressure. For this reason there is no significant relationship with the cause of diabetic nephropathy, but the time course of the disease to hypertension or microalbuminuria period after blood pressure can accelerate the deterioration of the progress of diabetic nephropathy and renal function, increased urinary excretion of albumin in some family history of hypertension in diabetic patients, the incidence of diabetic nephropathy was significantly higher than in patients with no family history of hypertension.
3, hyperglycemia. This factor and lead to a great relationship with diabetic nephropathy, diabetic nephropathy and high blood sugar closely related to poor glycemic control can accelerate the development of diabetic nephropathy, a good blood glucose control can significantly slow down its development. After the high blood sugar and glycation endproducts cause increased mesangial cell proliferation, extracellular matrix increased mesangial expansion, glomerular basement membrane thickening.
4, renal hemodynamic abnormalities. In diabetic nephropathy, and played a key role, and may even be the initial factor.
(1) high blood sugar, high glomerular perfusion, high filtration state, increased pressure across the capillary wall, the expansion of mesangial cells, epithelial cell foot process fusion and produce dense droplets, glomerular epithelial cells from the basal membrane shedding.
(2) the glomerular basement membrane collagen Ⅳ messenger sugar nucleic acid increased, the basement membrane thickening, and ultimately the formation of diffuse mesangial nodular lesions occur glomerulosclerosis.
(3) In the case of increased pressure, increased protein filtration, also deposited in the mesangial area and glomerular basement membrane, promoting stromal proliferation, creating a vicious cycle, and can cause nodular and diffuse glomerulosclerosis .
Presentation we saw above, for the cause of diabetic nephropathy, and now no stranger to it, and today I will introduce here first, hoping to help everyone, our preventive aspects in life from diabetic nephropathy The work, so that we can stay away from the disease, I wish you health.