Nephrotic syndrome can be applied tripterygium treated?

Energy . Division of Wei Mao Tripterygium wilfordii species, also known as Huang Teng , Gelsemium elegans and so on. The main effect of expelling dampness , promoting blood circulation . Since the 1970s for the treatment of rheumatoid arthritis and skin diseases . Achieved good results. Further studies confirmed by modern pharmacology , triptolide has anti-inflammatory and immune suppression, the role of microcirculation , therefore , has been widely used for the treatment of renal disease , its primary nephrotic syndrome type I , especially pathological type as minimal change who alone should
Can achieve good results with , for primary nephrotic syndrome type II or secondary nephrotic syndrome ( such as lupus nephritis, purple move nephritis ) also have a certain effect , if the hormone is effective with the use of better and may reduce recurrence and improve kidney function .
Side effects of Tripterygium how to prevent?
Tripterygium as poisonous plants , their roots, stems, leaves, flowers are poisonous . The main toxic components of Tripterygium diterpenoid . Followed alkaloids, triterpenoids and glycosides . Diterpenoid major damage the heart, liver , gastrointestinal tract and bone marrow , alkaloids major damage to the liver, toxicity total glycosides and alkaloids than the crude drug is much smaller . Its symptoms mainly as hyperemesis gravidarum , abdominal cramps , diarrhea, fast heart sounds weak , ECG changes , hypotension , hypothermia , shock, oliguria, edema , urine abnormality , the late occurrence of bone marrow suppression , mucosal erosion , hair loss , etc. individual may have convulsions. Main died of circulatory failure and renal failure , if not for blood purification therapy , and more died within 24 hours , usually no more than 4 days, the side effects of Tripterygium is more common gastrointestinal reactions , including loss of appetite , burning the lower part of the esophagus , nausea , vomiting, dry mouth , bowel . White blood cells and may also occur thrombocytopenia , but lighter , easy recovery, often in combination with corticosteroids does not appear , certain autoimmune diseases such as systemic lupus red Lian -induced thrombocytopenia fine white chest and in the treatment with the drug after some anti may rebound. Women with menstrual disorders and menopause are more common, reusable after stopping the tide . Reduce the number of skilled men visible , can be restored after treatment. Also still occasionally eczema -like rash , dry skin, pigmentation , itching , perioral herpes, angular stomatitis , mucosal ulcers, hair loss and a minority view (toe ) A thinning and softening .
In the clinical setting, to prevent the toxic effects of Tripterygium should do the following:
( 1 ) Thunder medicinal fat should be drawn to the two-story wooden root bark of the root portion of the heart into pieces medicine, and more gently for two hours with the text , ( 2 ) a daily dose of birth control drugs should be less than 20g, tripterygium glycosides serving 30 ~ 60mg tablets a day, 3 times service (all adult amount ) is appropriate.
( 3 ) because of side effects tripterygium mostly in the early treatment , so before treatment and 3 to 4 weeks of initial treatment should be a weekly routine, liver function, electrocardiogram , if necessary, with the application of some or white blood cells or protect the gastric mucosa of Chinese and Western medicine , such as medicine , leucogen , vitamin B4, hepatic blood Po , sucralfate tablets , medicine heterophylla , Atractylodes , Salvia, licorice , angelica, Agrimony , dates , etc. on the gastrointestinal tract obvious when or after a meal can be a method of medication once or adverse GPT elevated white blood cell <4.0X10'' / L , etc. appear , should be promptly discontinued .